Don't get discouraged with Twitter. There are many of us who try and respond personally to every DM and @reply. Just be you is the best advice. I have met many great people through Twitter..mostly just by everyday "conversation" and then eventually an email and then a phone call. Many have become business contacts..but it began with getting to know each other. Think of it as a process, just like getting to know new people in real life.
I respond to you on twitter and you do the same back to me. Just stay on that track. Look for interesting things that people are saying and put in your two cents..that's what gets conversations going in 140 characters. Some will respond. Some won't. Pay attention to those who do.
Someone asked, "How do people find me"..on twitter. They can go to search.twitter.com and put in a keyword..More likely, they start following people that someone else is following..or you follow them and then they follow you.
Enjoy twitter guys. It is the best way to make connections that is also fast and fun. I even just wrote a blog post about Twitter Guilt
..because it is so fun and still so worthwhile for business.